Autoinduction of tumor necrosis factor-α in FRTL-5 rat thyroid cells
نویسندگان
چکیده
منابع مشابه
Autoinduction of tumor necrosis factor- in FRTL-5 rat thyroid cells
Tumor necrosis factor(TNF ) may play a role in the development of autoimmune thyroiditis such as Hashimoto’s thyroiditis. In the present study, we examined whether TNF induced its own expression in FRTL-5 rat thyroid cells. Lipopolysaccharide (LPS) markedly increased TNF mRNA levels in FRTL-5 cells as assessed by semiquantitative RT-PCR. In addition, LPSstimulated cells released TNF protein int...
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Thyroid transcription factor 1 (TTF-1) is thought to play an important role in the expression of genes that encode thyroid-specific proteins such as thyroglobulin, thyroid peroxidase, and TSH-receptor. The role of TSH in the regulation of TTF-1 messenger RNA (mRNA) and protein abundance was investigated in rat thyroid FRTL-5 cells. Northern blot analysis revealed that TSH reduced TTF-1 mRNA abu...
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NVe studied the inhibitory effect of iodide on thyroid growtlk iR FRTL-5 cells, which pyeserve many thyroid functions, When the amount of iodide in medium exceeds IO-6 M, TSH-stimulated [3H]thymidine incorporation into DNA was sigRificantly inhibited. Methimazole (O.:5 mM> reversed the suppression, as was observed in other functions such as thyroid hormone synthesis and secretion. Cell numbers ...
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Background: It has been suggested that inflammation might be implicated in the gestational diabetes mellitus (GDM) complications, including insulin resistance. The aims of the current study were to explore maternal circulating values of TNF-α, adiponectin and the adiponectin/TNF-α ratio in women with GDM compared with normal pregnancy and their relationships with metabolic syndrome ...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2005
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.1.05887